protein TUNAR; pTUNAR; beta cell & neural cell-regulin; BNLN; TCL1 upstream neural differentiation-associated RNA (TUNAR)

Function

• in neurons, plays a role in the regulation of intracellular Ca+2, possibly by acting as an activator of ATP2A2/SERCA2, thus increasing the efficiency of Ca+2 removal from the cytoplasm (putative)
• inhibits differentiation of embryonic stem cells into neurons & inhibits neurite outgrowth, as a result of its role in intracellular Ca+2 regulation (putative)
• in pancreatic beta cells, lowers Ca+2 levels in the endoplasmic reticulum & enhances glucose-stimulated insulin secretion
• interacts with ATPase ATP2A2/SERCA2 (putative)
• interacts with ATPase ATP2A3/SERCA3
  • occurs at low levels in low glucose conditions; increased by high glucose levels

Compartment

• single-pass membrane protein
• endoplasmic reticulum membrane
• extracellular vesicle membrane

Expression

• highly expressed in pancreatic islets
  • enriched in insulin-producing beta cells

More general terms

• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/A0A1B0GTB2.html