sarcoplasmic/endoplasmic reticulum Ca+2 ATPase 3; Ca+2 transporting ATPase 3; Ca+2 pump 3; R Ca+2-ATPase 3 (SERCA3, ATP2A3)

Function

• catalyzes the hydrolysis of ATP coupled with the transport of calcium from cytosol into sarcoplasmic reticulum/endoplasmic reticulum lumen, magnesium dependent
• contributes to calcium sequestration in muscular excitation/ muscle contraction

Alternative splicing

6 isoforms; SERCA3A-3F

Expression

• in most tissues
• highest in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas & colon
• found in fetal tissue

Pathology

• expression significantly decreased in colon adenocarcinomas compared to normal

Genetics

gene locus: 17p13.3

More general terms

• sarcoplasmic/endoplasmic reticulum calcium ATPase

Database

• OMIM: https://mirror.omim.org/entry/601929
• UniProt: http://www.uniprot.org/uniprot/Q93084.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=489