sarcoplasmic/endoplasmic reticulum Ca+2 ATPase 2; Ca+2 ATPase of endoplasmic/sarcoplasmic reticulum; Ca+2 ATPase slow-twitch (SERCA2)
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Introduction
Sarcoplasmic & endoplasmic reticulum Ca+2-ATPase of slow twitch skeletal muscle & cardiac muscle.
Function
- catalyzes hydrolysis of ATP coupled with translocation of Ca+2 from cytosol to sarcoplasmic reticulum lumen
- SERCA2A isoform involved in regulation of contraction- relaxation cycle
- associates with phospholamban
- reversibly inhibited by phospholamban at low Ca+2 concentrations
- dephosphorylated phospholamban decreases apparent affinity of the ATPase for Ca+2
- inhibition is regulated by the phosphorylation of phospholamban (putative)
Compartment
- endoplasmic reticulum membrane
- sarcoplasmic reticulum membrane
Alternative splicing
named isoforms=2; SERCA2A, SERCA2B
Expression
- isoform SERCA2A is highly expressed in heart & slow twitch skeletal muscle
- isoform SERCA2B is widely expressed, in smooth muscle & nonmuscle tissues including adult skin epidermis
- expression inhibited by miR-25[5]
Pathology
- defects associated with
- Darier's disease
- acrokeratosis verruciformis (Hopf disease)
- lower levels associated with heart failure[5]
Genetics
gene locus: 12q23-q24.1
More general terms
References
- ↑ Carafoli E. Biogenesis: plasma membrane calcium ATPase: 15 years of work on the purified enzyme. FASEB J. 1994 Oct;8(13):993-1002. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7926378
- ↑ OMIM https://mirror.omim.org/entry/108740
- ↑ UniProt http://www.uniprot.org/uniprot/P16615.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ATP2A2
- ↑ 5.0 5.1 5.2 Wahlquist C et al. Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature 2014 Apr 24; 508:531. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24670661