sarcoplasmic/endoplasmic reticulum Ca+2 ATPase 2; Ca+2 ATPase of endoplasmic/sarcoplasmic reticulum; Ca+2 ATPase slow-twitch (SERCA2)

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Introduction

Sarcoplasmic & endoplasmic reticulum Ca+2-ATPase of slow twitch skeletal muscle & cardiac muscle.

Function

Compartment

Alternative splicing

named isoforms=2; SERCA2A, SERCA2B

Expression

Pathology

Genetics

gene locus: 12q23-q24.1

More general terms

References

  1. Carafoli E. Biogenesis: plasma membrane calcium ATPase: 15 years of work on the purified enzyme. FASEB J. 1994 Oct;8(13):993-1002. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7926378
  2. OMIM https://mirror.omim.org/entry/108740
  3. UniProt http://www.uniprot.org/uniprot/P16615.html
  4. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ATP2A2
  5. 5.0 5.1 5.2 Wahlquist C et al. Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature 2014 Apr 24; 508:531. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24670661

Database