epigenetic disease
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Genetics
- epigenetic instability may be a central feature of cancer
- neoplasms are associated with widespread losses & some gains of DNA methylation throughout the genome
- differences in neoplasms are related to the tissue of origin & spectrum of mutations associated with that organ
- properties of neoplasm heterogeneity & therapeutic resistance are epigenetic & shared among neoplasms
- epigentic changes appear to drive metastases
- epigenetic changes occur with aging
- in vitro manipulations can reverse the age-related epigenetic changes
- a combination of 3 genes (Oct4, KLF4, SOX2) into mouse & human retinal neurons can restore a youthful epigenetic pattern & enhance regeneration following injury
- viral vector carrying these 3 genes injected it into vitreous humor of mice going blind from aging fully restored vision
- correlate age-related macular degeneration?[2]
- if 3 genes transfected viral vector injected into aqueous humor of mice going blind from glaucoma, ~50% of vision restored[2]
More general terms
Additional terms
References
- ↑ Feinberg AP The Key Role of Epigenetics in Human Disease Prevention and Mitigation. N Engl J Med 2018; 378:1323-1334. April 5, 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29617578 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMra1402513
- ↑ 2.0 2.1 2.2 Lu Y, Brommer B, Tian X et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature 2020 Dec; 588:124-129 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33268865 https://www.nature.com/articles/s41586-020-2975-4
- ↑ Cavalli G, Heard E. Advances in epigenetics link genetics to the environment and disease. Nature. 2019;571(7766):489-499 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31341302 https://www.nature.com/articles/s41576-018-0004-3