epigenetic disease

From Aaushi
Jump to navigation Jump to search

Genetics

malignant neoplasms

aging

- a combination of 3 genes (Oct4, KLF4, SOX2) into mouse & human retinal neurons can restore a youthful epigenetic pattern & enhance regeneration following injury

eye disease

More general terms

Additional terms

References

  1. Feinberg AP The Key Role of Epigenetics in Human Disease Prevention and Mitigation. N Engl J Med 2018; 378:1323-1334. April 5, 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29617578 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMra1402513
  2. 2.0 2.1 2.2 Lu Y, Brommer B, Tian X et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature 2020 Dec; 588:124-129 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33268865 https://www.nature.com/articles/s41586-020-2975-4
  3. Cavalli G, Heard E. Advances in epigenetics link genetics to the environment and disease. Nature. 2019;571(7766):489-499 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31341302 https://www.nature.com/articles/s41576-018-0004-3