chorionic somatomammotropin hormone 2; choriomammotropin-2 (CSH2)
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Function
- produced only during pregnancy
- role in stimulating lactation, fetal growth & metabolism
- does not interact with GHR
- only activates PRLR through Zn+2-induced dimerization[2]
Structure
- belongs to the somatotropin/prolactin family
- CSH2 sequence only differs from CSH1 sequence in 1 amino acid residue
- can be found in a monomeric as well as dimeric form[3]
Compartment
Alternative promoter usage
Named isoforms=3
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P0DML3.html
- ↑ 2.0 2.1 Walsh ST, Kossiakoff AA. Crystal structure and site 1 binding energetics of human placental lactogen. J Mol Biol. 2006 May 5;358(3):773-84. Epub 2006 Mar 2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16546209
- ↑ 3.0 3.1 Schneider AB, Kowalski K, Russell J, Sherwood LM. Identification of the interchain disulfide bonds of dimeric human placental lactogen. J Biol Chem. 1979 May 25;254(10):3782-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/438159