chorionic somatomammotropin hormone 1; choriomammotropin-1 (CSH1)

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^[1]^[2]^[3]

Function

produced only during pregnancy
role in stimulating lactation, fetal growth & metabolism
does not interact with GHR
only activates PRLR through Zn+2-induced dimerization^[2]

Structure

belongs to the somatotropin/prolactin family
CSH1 sequence only differs from CSH2 sequence in 1 amino acid residue
can be found in a monomeric as well as dimeric form^[3]

Compartment

More general terms

chorionic somatomammotropin hormone

References

↑ UniProt http://www.uniprot.org/uniprot/P0DML2.html
↑ ^2.0 ^2.1 Walsh ST, Kossiakoff AA. Crystal structure and site 1 binding energetics of human placental lactogen. J Mol Biol. 2006 May 5;358(3):773-84. Epub 2006 Mar 2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16546209
↑ ^3.0 ^3.1 Schneider AB, Kowalski K, Russell J, Sherwood LM. Identification of the interchain disulfide bonds of dimeric human placental lactogen. J Biol Chem. 1979 May 25;254(10):3782-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/438159

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1442
OMIM: https://mirror.omim.org/entry/150200
UniProt: http://www.uniprot.org/uniprot/P0DML2.html

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