C5a anaphylatoxin chemotactic receptor 2; complement component 5a receptor 2; G-protein coupled receptor 77 (C5AR2, C5L2, GPR77)

Function

• receptor for the chemotactic & inflammatory C3a, C4a & C5a anaphylatoxins & for their dearginated forms ASP/C3adesArg, C4adesArg & C5adesArg respectively
• couples weakly to Gi-mediated signaling pathways
• interacts with C3 (the anaphylatoxin peptide C3a & the adipogenic hormone ASP)
  • interaction occurs with higher affinity for ASP, enhancing the phosphorylation & activation of GPR77, recruitment of ARRB2 to the cell surface & endocytosis of GRP77

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed in frontal cortex, hippocampus, hypothalamus, pons, liver

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27202
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27202
• OMIM: https://mirror.omim.org/entry/609949
• UniProt: http://www.uniprot.org/uniprot/Q9P296.html