fluoropyrimidine

Adverse effects

• cardiovascular
  • arrhythmias
  • myocardial infarction
  • cardiogenic shock
• mechanisms of pathology:
  • coronary vasospasm
  • direct myocardial toxicity due to mitochondrial injury
  • endothelial dysfunction
  • ferroptosis
• management of adverse effects:
  • discontinuation of offending agent
  • calcium channel blocker &/or nitrates to treat vasospasm

• drug adverse effects of fluoropyrimidines

More general terms

• pyrimidine antimetabolite; antimetabolite; pyrimidine analog

More specific terms

• 5-fluorouracil [5-FU] (Fluoroplex, Efudex, Adrucel, Carac)
• capecitabine (Xeloda)
• floxuridine; fluorodeoxyurine; 2'-Deoxy-5-fluorouridine