floxuridine; fluorodeoxyurine; 2'-Deoxy-5-fluorouridine

Indications

• gastrointestinal cancer (adenocarcinoma) with liver metastases

Dosage

• for intra-arterial infusion only
• 0.1 to 0.6 mg/kg/day
• doses of 0.4 to 0.6 mg for hepatic artery infusion
• reconstituted with 5 mL of sterile water for injection to yield a solution containing approximately 100 mg/mL of floxuridine
• the calculated daily dose(s) of the drug is then diluted with 5% dextrose or 0.9% sodium chloride injection to a volume appropriate for the infusion apparatus to be used
• therapy can be given until adverse reactions appear

Adverse effects

• procedural complications of regional arterial infusion (most common)
• common: nausea, vomiting, diarrhea, enteritis, stomatitis, localized erythema
• common laboratory abnormalities:
  • anemia, leukopenia, thrombocytopenia
  • elevations of serum alkaline phosphatase, serum AST, serum ALT, serum bilirubin & serum lactic dehydrogenase

More general terms

• fluoropyrimidine
• antineoplastic agent (chemotherapeutic agent)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5790
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=43834572
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=643968
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46781591
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=22824722