nascent polypeptide-associated complex subunit alpha, muscle-specific form; alpha-NAC, muscle-specific form; skNAC (NACA-M)

Function

• cardiac- & muscle-specific transcription factor
• may act to regulate the expression of genes involved in the development of myotubes
• role in ventricular cardiomyocyte expansion
• regulates postnatal skeletal muscle growth & regeneration
• role in the organized assembly of thick & thin filaments of myofibril sarcomeres (putative)
• interacts (via PXLXP motif)
• interacts with the muscle-restricted histone methyltransferase SMYD1 (via MYND-type Zn+2 finger)

Structure

• the proline-rich muscle-specific exon 3 contains 18 approximate 23-AA repeats
• contains 1 NAC-A/B (NAC-alpha/beta) domain
• contains 1 UBA domain

Compartment

• cytoplasm (putative)
• nucleus Alternative
• splicing: named isoforms=3

More general terms

• nascent polypeptide-associated complex subunit alpha

Database

• UniProt: http://www.uniprot.org/uniprot/E9PAV3.html