nascent polypeptide-associated complex subunit alpha (NAC-alpha, alpha-NAC, Hom s 2.02, NACA)

Function

• component of nascent polypeptide-associated complex
• may act as a specific coactivator for JUN, binding to DNA & stabilizing interaction of JUN homodimers with target gene promoters
• interacts with TBP & JUN
• phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization
• phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation

Structure

• belongs to the NAC-alpha family
• contains 1 NAC-A/B domain (NAC-alpha/beta domain)
  • contains 1 UBA domain

Compartment

cytoplasm, nucleus, predominantly cytoplasmic

Pathology

• allergen; causes an allergic reaction in human
• binds to IgE in patients with atopic dermatitis
• identified as an IgE autoantigen in patients with atopic dermatitis with severe skin manifestations

More general terms

• protein subunit
• DNA-binding protein
• phosphoprotein

More specific terms

• nascent polypeptide-associated complex subunit alpha, muscle-specific form; alpha-NAC, muscle-specific form; skNAC (NACA-M)

Component of

• nascent polypeptide-associated complex (NAC)

Database

• OMIM: https://mirror.omim.org/entry/601234
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4666
• UniProt: http://www.uniprot.org/uniprot/Q13765.html