cutaneous papillomatosis

Etiology

• occurs in association with malignant acanthosis nigricans & an internal malignancy, generally gastric cancer
  • less commonly bladder cancer, ovarian cancer, breast cancer, biliary carcinoma, lung squamous cell carcinoma, non-Hodgkin's lymphoma

Pathology

• hyperplasia & enlargement of contiguous dermal papillae
• hyperkeratosis, acanthosis, & papillomatosis
• no evidence of epidermal vacuolization, parakeratosis, or eosinophilic inclusions suggestive of viral warts

Clinical manifestations

• rapid onset of numerous warty papules on the trunk & extremities, clinically indistinguishable from viral warts

Laboratory

• papillomavirus DNA negative

Management

• treatment of underlying malignancy

More general terms

• paraneoplastic syndrome
• papillomatosis
• skin disease (dermatologic disorder, dermatopathy, dermatosis)