2'-deoxynucleoside 5'-phosphate N-hydrolase 1; deoxynucleoside 5'-phosphate N-glucosidase; c-Myc-responsive protein RCL (DNPH1, C6orf108, RCL)

Function

• catalyzes cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate & a purine or pyrimidine base
• deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases (putative)
• may play a role in the cell-cycle

Structure

• monomer & homodimer (putative)
• belongs to the deoxyribonucleoside 5'-monophosphate N-glycosidase family

Compartment

nucleus (putative). cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, & thymus
• expressed at high levels in heart, kidney, liver, skeletal muscle & spleen
• expression: Expression is induced by ETV1

Pathology

• overexpressed in a significant proportion of breast cancers
• may play a role in c-Myc-mediated transformation

More general terms

• glycosidase (glycoside hydrolase)
• nuclear protein
• phosphoprotein

Additional terms

• c-myc proto-oncogene protein; transcription factor p64 (c-Myc, MYC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10591
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10591
• UniProt: http://www.uniprot.org/uniprot/O43598.html