multicilin; multiciliate differentiation & DNA synthesis-associated cell cycle protein; protein Idas (MCIDAS, IDAS, MCI, MCIN)

Function

• transcription regulator required for multiciliate cell differentiation
• acts by promoting transcription of genes required for multiciliate cell formation
• probably acts in a multiprotein complex (putative)
• plays a role in mitotic cell cycle progression by promoting cell cycle exit
• interacts with GMNN; targets GMNN to the nucleus
• prevents GMNN interaction with CDT1 & competes with IDAS homodimerization

Structure

• homodimer
• belongs to the geminin family

Compartment

• nucleus
• excluded from the nucleolus

Expression

• probable target of the anaphase promoting complex/cyclosome (APC/C) which regulates its level in the cell during the mitotic cell cycle
• highly expressed during interphase & early mitosis
• expression decreases during anaphase to become undetectable during telophase & cytokinesis

Notes

• was named Idas in reference to the cousin of the Gemini in ancient greek mythology

More general terms

• transcription factor (TF)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=345643
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:345643
• OMIM: https://mirror.omim.org/entry/614086
• UniProt: http://www.uniprot.org/uniprot/D6RGH6.html