avanafil (Stendra)

Indications

• treatment of erectile dysfunction

Contraindications

• creatinine clearance < 30 ml/min
• liver failure

Dosage

• 50-200 mg 30 minutes prior to sexual activity

Pharmacokinetics

• duration of about 5 hours, similar to Viagra, Levitra

Adverse effects

• headache, back pain, flushing, headache, nasal congestion, pharygitis
• priapism (rare)

• drug adverse effects of phosphodiesterase-5-inhibitors
• drug adverse effects of antihypertensive agents

Drug interactions

• hypotension in combination with nitrates
• prone to CYP3A4 interactions
  • avoid it with strong inducers of CYP3A4 (phenytoin) or strong inhibitors (itraconazole)

• drug interaction(s) of nitrates with phosphodiesterase-5-inhibitors
• drug interaction(s) of phosphodiesterase-5-inhibitor with testosterone
• drug interaction(s) of phosphodiesterase-5-inhibitor with nitrates
• drug interaction(s) of phosphodiesterase-5-inhibitors with alpha-1-adrenergic receptor antagonists
• drug interaction(s) of NSAIDs & antihypertensives

More general terms

• phosphodiesterase-5 inhibitor