cholera vaccine (Vibrio cholerae vaccine, Shanchol, Vaxchora)

^[1]^[2]^[3]^[4]

Introduction

Vaxchora FDA-approved June 2016

immunization against Vibrio cholerae infection (cholera)
- prevention of cholera (serogroup O1) in adults aged 18-64 years visiting cholera-affected areas^[3]^[4]

Vaxchora's safety & effectiveness not established in immunocompromised patients^[3]

oral cholera vaccine Shanchol^[2]
- 2 doses at least 14 days apart
- 37% effective for 1 dose, > 50% effective for 2 doses
Vaxchora: single liquid dose (~ 3 oz) at least 10 days before travel^[3]

↑ CPT
↑ ^2.0 ^2.1 Qadri F et al Feasibility and effectiveness of oral cholera vaccine in an urban endemic setting in Bangladesh: a cluster randomised open-label trial. Lancet. July 8, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26164097 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2961140-0/abstract
O'Leary M, Mulholland K Oral cholera vaccines in endemic countries. Lancet. July 8, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26164098 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2960246-X/abstract
↑ ^3.0 ^3.1 ^3.2 ^3.3 FDA News Release. June 10, 2016 FDA approves vaccine to prevent cholera for travelers. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm506305.htm
↑ ^4.0 ^4.1 ^4.2 ^4.3 Wong KK, Burdette E, Mahon BE, Mintz ED, Ryan ET, Reingold AL. Recommendations of the Advisory Committee on Immunization Practices for Use of Cholera Vaccine. MMWR Morb Mortal Wkly Rep 2017;66:482-485 https://www.cdc.gov/mmwr/volumes/66/wr/mm6618a6.htm