phenylbutyrate (Buphenyl, Olpruva)

Indications

• used to treat urea cycle disorder by facilitating clearance of ammonia
• shows promise in treatment of diabetes mellitus type 2

Dosage

• oral dose based on size: < 20 grams (40 tablets)/day
• given in divided doses 3-6 times/day with meals

Tablets: 500 mg

Adverse effects

• common
  • change in frequency of breathing
  • irregular menstruation
  • low back pain
  • stomach pain
  • mood or mental changes
  • myalgia, muscle twitching
  • nausea, vomiting
  • nervousness or restlessness
  • pedal edema
  • dysgeusia
  • fatigue or weakness
• less common
  • fever, chills
  • arthralgia
  • sore throat
  • unusual bleeding or bruising
• rare
  • seizures
  • dizziness
  • dryness of the mouth
  • palpitations
  • hypertension
  • increased thirst
  • irritability
  • muscle cramps
  • rectal bleeding
  • swelling of the face
  • unusual weight gain
  • weak pulse

Mechanism of action

• improves peripheral insulin sensitivity & glucose oxidation

More general terms

• carboxylate
• metabolic agent (metabolic modifier)

Component of

• sodium phenylbutyrate/tauroursodeoxycholic acid; sodium phenylbutyrate/taurursodiol (Relyvrio, AMX0035)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5258