cyclopentolate/phenylephrine (Cyclomydril)

Indications

• induction of mydriasis & cycloplegia in diagnostic procedures

Contraindications

glaucoma

Dosage

• 1 drop every 5-10 minutes
• do NOT exceed 3 times
• apply finger pressure to lacrimal sac during & 1-2 minutes following application for medication to reduce frequency of systemic side effects

Pharmacokinetics

• maximal mydirasis & cycloplegia in 15-60 minutes
• usual duration of action 24 hours

Adverse effects

• burning senstation (frequent)
• blurred vision
• sensitivity to light
• local irritation
• increased intraocular pressure

Mechanism of action

• cyclopentolate blocks action of acetylcholine
• phenylephrine stimulates alpha-1 receptors

More general terms

• pharmacologic combination

Components

• cyclopentolate (Cyclogyl)
• phenylephrine (Neo-Synephrine, Mydrifin, sudafed PE, PE)