cyclopentolate (Cyclogyl)

Introduction

Tradename: Cyclogyl.

Indications

• induction of mydriasis & cycloplegia for procedures
• uveitis, posterior synechiae

Dosage

• 1 drop followed by another in 5 minutes
• give 40-50 minutes prior to procedure
• apply finger to lacrimal sac during & for 1-2 minutes following instillation to reduce frequency of systemic adverse effects
• Mydriasis: 1 drop QD-TID for 1-2 days
• Cycloplegia: 1 drop QD-TID for 1-2 days
• use 0.5% solution for children

Ophthalmic: 0.5 % 1.2%

Pharmacokinetics

• maximal mydriasis & cycloplegia in 15-60 minutes
• usual duration of action is 24 hours

Adverse effects

• not common (1-10%)
  • tachycardia, restlessness, hallucination, psychosis, hyperactivity, seizures, incoherent speech, ataxia, burning sensation, increased intraocular pressure, loss of visual accomodation, allergic reactions

• drug adverse effects of parasympatholytics

Mechanism of action

• blocks cholinergic stimulation in the ciliary body & sphincter muscle of the iris

More general terms

• parasympatholytic (anticholinergic, antimuscarinic agent)
• mydriatic agent
• cycloplegic agent

Component of

• cyclopentolate/phenylephrine (Cyclomydril)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2905
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=22162
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=657209