protein kinase C & casein kinase substrate in neurons protein 2 (PACSIN2)

Function

• may play a role in vesicle formation & transport
• phosphorylated by casein kinase 2 (CK2) & protein kinase C (PKC) (putative)
• homo- & hetero-aggregates with other PACSINs
• binds dynamin 1, synaptojanin, synapsin 1 & the neural Wiskott-Aldrich syndrome protein (N-WASP) (putative)

Structure

• belongs to the PACSIN family
• contains 1 FCH domain
• contains 1 SH3 domain

Compartment

• cytoplasmic vesicle (putative)
• vesicle-like cytoplasmic distribution (putative)

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

More general terms

• protein kinase c & casein kinase substrate in neurons protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11252
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11252
• OMIM: https://mirror.omim.org/entry/604960
• UniProt: http://www.uniprot.org/uniprot/Q9UNF0.html