protein kinase C & casein kinase substrate in neurons protein 1 (PACSIN1, KIAA1379)

Function

• may play a role in vesicle formation & transport
• phosphorylated by casein kinase 2 (CK2) & protein kinase C (PKC) (probable)
• homo- & hetero-aggregates with other PACSINs
• binds dynamin-1, synaptojanin, synapsin-1 & the neural Wiskott-Aldrich syndrome protein (N-WASP) (putative)

Structure

• belongs to the PACSIN family
• contains 1 FCH domain
• contains 1 SH3 domain

Compartment

• cytoplasm (putative)
• colocalizes with dynamin-1 at vesicular structures in the cell body & neurites (putative)

Expression

• highly expressed in brain
• expressed to a lesser extent in heart, pancreas & liver

More general terms

• protein kinase c & casein kinase substrate in neurons protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29993
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29993
• OMIM: https://mirror.omim.org/entry/606512
• UniProt: http://www.uniprot.org/uniprot/Q9BY11.html