Myb-related protein p42POP; partner of profilin (P42POP, MYPOP)

Function

• transcriptional repressor
• DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'
• dimerization with PFN1 reduces its DNA-binding capacity
• interacts with PFN1
• homodimer & heterodimer with PFN1

Structure

• proline-rich region is required for PFN1 interaction
• contains 1 Myb-like domain

Compartment

nucleus (putative)

More general terms

• transcriptional silencer (transcriptional repressor)
• DNA-binding protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3393
• UniProt: http://www.uniprot.org/uniprot/Q86VE0.html