microtubule-associated proteins 1A/1B light chain 3B-like protein (MAP1LC3B2, MAP1A/1B, 3BL)

Function

• role in formation of autophagosomal vacuoles (autophagosomes) (putative)
• 3 different light chains, LC1, LC2 & LC3, can associate with MAP1A & MAP1B proteins (putative)
• precursor molecule is cleaved by APG4B/ATG4B to form LC3-I (putative); this is activated by APG7L/ATG7, transferred to ATG3 & conjugated to phospholipid to form LC3-II

Structure

belongs to the MAP1 LC3 family

Compartment

• cytoplasm, intracytoplasmic membrane; lipid-anchor (putative)
• cytoplasmic vesicle, autophagosome membrane; lipid-anchor (putative)

More general terms

• uncharacterized protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6432
• UniProt: http://www.uniprot.org/uniprot/A6NCE7.html