autophagy 4 homolog B; cysteine protease ATG4B; AUT-like 1 cysteine endopeptidase; autophagin-1; autophagy-related cysteine endopeptidase 1; autophagy-related protein 4 homolog B; hAPG4B (ATG4B, APG4B, AUTL1, KIAA0943)
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Function
- cysteine protease required for autophagy
- cleaves C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I
- a subpopulation of form I is subsequently converted to a smaller form (form II)
- form II, with a revealed C-terminal GLY, is considered to be the phosphatidylethanolamine-conjugated form, & has the capacity for the binding to autophagosomes
Inhibition:
- inhibited by N-ethylmaleimide
Structure
belongs to the peptidase C54 family
Compartment
cytoplasm (probable)
Alternative splicing
named isoforms=5
Expression
- expressed in the skeletal muscle > brain, heart, liver & pancreas