diagnostic criteria for multiple myeloma

Diagnostic criteria

• International Myeloma Working Group
  • monoclonal plasma cells in the bone marrow > 10% &/or presence of biopsy-proven plasmacytoma
  • monoclonal protein in the serum &/or urine
  • myeloma-related organ dysfunction (1 or more)
    • serum Ca+2 > 10.5 mg/dL (2.63 mmol/L)
    • serum creatinine > 2 mg/dL (153 umol/L)
    • hemoglobin < 10 g/dL
    • lytic bone lesions or osteoporosis
• World Health Organization (WHO)
  • major criteria
    • plasmacytoma on tissue biopsy
    • bone marrow clonal plasma cells > 30%
    • high M protein on serum protein electrophoresis (IgG > 3.5 g/dL; IgA > 2.0 g/dL) or Bence-Jones protein in urine > 1.0 g/24 hours
  • minor criteria
    • bone marrow clonal plasma cells 10-30%
    • M protein not reaching major criteria
    • lytic bone lesions
    • diminished normal immunoglobulins to < 50% of normal

More general terms

• criteria

Additional terms

• multiple myeloma; plasmacytoma/plasma cell myeloma