endogenous retroviral REC protein

Introduction

Endogenous retroviral proteins may have kept, lost or modified their original function during evolution.

Function

• Rec interacts with an RNA element (RcRE) present in viral 3'LTR & recruits the cellular nuclear export machinery
• this permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts
• associates with XPO1 & with ZNF145

Structure

• forms homodimers, homotrimers, & homotetramers via a C-terminal domain
• despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev & HTLV-1 Rex

Compartment

• nucleus, nucleolus
• shuttles between the nucleus & cytoplasm
• when in the nucleus, resides in the nucleolus

More general terms

• endogenous retroviral protein

More specific terms

• HERV-K 10p14 provirus Rec protein
• HERV-K 11q22.1 provirus Rec protein
• HERV-K 12q14.1 provirus Rec protein
• HERV-K 19p13.11 provirus Rec protein (HERV-K113 Rec protein)
• HERV-K 19q12 provirus Rec protein (HERV-K(C19) Rec protein)
• HERV-K 5q13.3 provirus Rec protein (HERV-K104 Rec protein)
• HERV-K 6q14.1 provirus Rec protein (HERV-K109 Rec protein, HERV-K(C6) Rec protein)
• HERV-K 7q22.1 provirus Rec protein; HERV-K (HML-2.HOM) Rec protein; HERV-K108 Rec protein; HERV-K(C7) Rec protein; central open reading frame; cORF; c-orf; Rev-like protein; Rev/Rex homolog; K-Rev (ERVK6, ERVK-6)
• HERV-K 8p23.1 provirus Rec protein (HERV-K115 Rec protein)