24-OH-cholesterol
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Introduction
24S-OH cholesterol is an endogenous ligand of LXR-alpha & LXR-beta. It is an enzymatically oxidized product of cholesterol, mainly synthesized in the brain via cholesterol 24-hydroxylase.[1] Conversion of cholesterol to 24-OH cholesterol may be the 1st step in eliminating cholesterol released from membranes. Crosses blood-brain barrier, picked up by LDL are transported back to the liver for elimination.[2]
See ref 3 for method of assay
More general terms
Additional terms
- cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1 (CYP46A1, CYP46)
- LX nuclear receptor (LXR, oxysterol receptor)
References
- ↑ 1.0 1.1 Ltjohann D, Papassotiropoulos A, Bjrkhem I, Locatelli S, Bagli M, Oehring RD, Schlegel U, Jessen F, Rao ML, von Bergmann K, Heun R. Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. J Lipid Res. 2000 Feb;41(2):195-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10681402, 2000
- ↑ 2.0 2.1 Vega GL et al Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease. Arch Neurol. 2003 Apr;60(4):510-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12707064