thiabendazole (Mintezol)
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Introduction
Tradename: Mintezol.
Indications
- treatment of hookworm, pinworm, roundworm, threadworm, whipworm, ascarids
- active against most intestinal nematodes
- trichinosis, uncinariasis, strongyloidiasis, trichuriasis, trichostrongyliasis, toxocariasis, cutaneous larva migrans[4]
Dosage
- take with meals
- 22 mg/kg up to 1500 mg PO BID.
- > 68 kg: 1.5 g PO BID for 2 days
- < 68 kg 1.0 g PO BID for 2 days
Tabs: 500 mg.
Suspension: 500 mg/5 mL.
Pharmacokinetics
- rapidly absorbed
- metabolized by the liver
- 90% eliminated in the urine
- most is eliminated from the plasma in 8 hours
elimination via feces
Adverse effects
- Frequent:
- Infrequent:
- Rare:
- Others[3]:
Up to 1/3 of patients administered thiabendazole are incapacitated for several hours by one or more symptoms
urine may exhibit a distinctive odor, much like asparagus does in some individuals
Mechanism of action
- complete helminth larvicidal activity occurs in vitro at a concentration of 10 pg/mL
- this potency, combined with the absence of activity against other micro-organisms & the relatively low mammalian toxicity, suggest interference with metabolic pathway(s) intrinsic to & essential for helminth development[1]
- it is suggested[3] that thiabendazoles interferes with helminth- specific fumarate reductase
- unlike mebendazole, thiabendazole is absorbed systemically & is effective against helminths that undergo systemic migration
More general terms
Component of
References
- ↑ Jump up to: 1.0 1.1 Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1990. pg 970
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Jump up to: 3.0 3.1 3.2 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
- ↑ Jump up to: 4.0 4.1 Deprecated Reference