benztropine <mesylate> (Cogentin)
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Introduction
Tradename: Cogentin.
Indications
- Parkinson's disease presenting primarily with tremor
- extrapyramidal reactions induced by antipsychotic agents
- exception is tardive dyskinesia[5]
- parkinsonism
- post-encephalitic parkinsonism[6]
Dosage
Tabs: 0.5, 1, 2 mg.
Injection: 1 mg/mL, 2 mL vials.
Adverse effects
- common (> 10%)
- constipation
- decreased sweating
- dry mouth, nose, throat or skin
- less common (1-10%)
- decreased flow of breast milk, difficulty swallowing photosensitivity
- uncommon (< 1%)
- skin rash, confusion especially in elderly, intraocular pain, orthostatic hypotension, bloating, urinary retention in men, blurred vision, closed-angle glaucoma, drowsiness, headache, loss of memory, nausea/vomiting, weakness, tiredness, ataxia, paralytic ileus, visual hallucinations, tachycardia, palpitations, ventricular fibrillation
Drug interactions
Laboratory
Mechanism of action
- anticholinergic agent
- little effect on hypokinesia or rigidity
More general terms
- pharmacologic agents for treatment of Parkinson's disease
- parasympatholytic (anticholinergic, antimuscarinic agent)
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
- ↑ The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 477
- ↑ Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 1052
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998.
- ↑ Jump up to: 5.0 5.1 Rosenheck R et al, JAMA 290:2693, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14645311
- ↑ Jump up to: 6.0 6.1 Deprecated Reference
- ↑ Department of Veterans Affairs, VA National Formulary
Database
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2344
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1201549
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6832
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441352
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=8584
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=238053