metipranolol (Optipranolol)

Introduction

Tradename: Optipranolol.

Indications

• increased intraocular pressure
• chronic open-angle glaucoma
• closed-angle glaucoma
• secondary glaucoma

Contraindications

Caution:

• bronchial asthma
• sinus bradycardia
• 2nd & 3rd degree AV block
• heart failure

Dosage

1 drop OU BID. 0.3% (5 mL, 10 mL).

Pharmacokinetics

• initial reduction of intraocular pressure in 30 minutes
• maximal reduction of intraocular pressure in 2 hours
• duration of action: up to 24 hours

Adverse effects

• common (> 10%)
  • mild ocular stinging & discomfort (transient, 56%)
  • eye irritation
• less common (1-10%)
  • blurred vision, eyebrow ache
• uncommon (< 1%)
  • conjunctivitis, blepharitis, bradycardia, AV block, congestive heart failure (CHF), asthenia, tearing, erythema, itching, keratitis, photophobia, decreased corneal sensitivity, bronchospasm

• drug adverse effects of beta-adrenergic receptor antagonists
• drug adverse effects of renin-angiotensin-aldosterone system inhibitors (RAAS inhibitors)
• drug adverse effects of antihypertensive agents

Mechanism of action

• non-selective beta blocker
• reduces aqueous humor production

More general terms

• non-specific beta-adrenergic receptor antagonist

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=31477
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=526482
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=656682
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=608246