risedronate (Actonel)
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Indications
- Paget's disease of the bone
- osteoporosis
- prevention of bone loss in multiple myeloma
- prevention of bone loss associated with corticosteroid therapy
- prevention of bone loss associated with hypogonadism =- androgen deprivation therapy
Dosage
- Paget's disease: 30 mg QD
- osteoporosis:
- do NOT take calcium at the same it as it may interfere with absorption
- take with full glass of water 30 minutes before 1st meal
- DO NOT LAY DOWN until after meal!
* bone loss after discontinuation of therapy may be greater for risedronate than alendronate or zoledronate[9]
Tabs: 5 mg, 35 mg for weekly dosing, 75 mg, 150 mg
Adverse effects
- similar to alendronate[6]
- erosive esophagitis
Mechanism of action
- binds to bone hydroxyapatite
- inhibits osteoclast activity
- diminishes risk of hip fractures, vertebral fractures & other factures[10]
More general terms
Additional terms
Component of
References
- ↑ The Prescriber's Letter, vol 6 #11, Nov 1999
The Prescriber's Letter, vol 7 #5, May 2000 - ↑ Journal Watch, Mass Med Soc 19(23):183 (Dec) 1999
- ↑ Journal Watch, Mass Med Soc 19(24):190 (Dec) 1999
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, Update 9/99
- ↑ Prescriber's Letter 7(8):47 2000
Prescriber's Letter 9(6):31 2002 - ↑ 6.0 6.1 Prescriber's Letter 10(8):47 2003
- ↑ Department of Veterans Affairs, VA National Formulary
- ↑ 8.0 8.1 Prescriber's Letter 14(6): 2007 New Developments With Bisphosphonate Therapy Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=230613&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 9.0 9.1 9.2 Whitaker M et al Bisphosphonates for Osteoporosis - Where Do We Go from Here? N Engl J Med 2012 May 9, <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22571168 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMp1202619
Black DM et al Continuing Bisphosphonate Treatment for Osteoporosis - For Whom and for How Long? N Engl J Med 2012 May 9, <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22571169 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMp1202623 - ↑ 10.0 10.1 Reid IR Efficacy, effectiveness and side effects of medications used to prevent fractures. J Intern Med. 2015 Jun;277(6):690-706 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25495429