cefditoren (Spectracef)

Introduction

Tradename: Spectracef. (cefditoren pivoxil)

Indications

• bacterial infection due to susceptible organisms
  • bronchitis (patients 12 & older)
  • pneumonia
  • pharyngitis (tonsillitis)
  • uncomplicated skin infections

Dosage

• 400 mg PO BID for 10 days (bronchitis)
• 200 mg PO BID for 10 days (skin infections, pharyngitis)

Tabs: 200 mg

Pharmacokinetics

• presumably metabolized in liver

elimination via liver

Antimicrobial activity

• Streptococcus
  • Streptococcus pneumoniae
  • Streptococcus pyogenes
• Haemophilus influenzae
• Haemophilus parainfluenzae
• Moraxella catarrhalis
• Staphylococcus aureus

Adverse effects

• one of its metabolites increases renal excretion of carnitine

• drug adverse effects of cephalosporins

Notes

Manufacturer: TAP pharmaceuticals

More general terms

• cephalosporin, 3rd generation

Additional terms

• carnitine (Carnitor)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=71311
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=444006
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5282187
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2621