carnitine (Carnitor)
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Introduction
Tradename: Carnitor.
Epidemiology
- abundant is red meat
Indications
- primary & secondary carnitine deficiency
- acute myocardial infarction
- not standard of yet care
- reduces all-cause mortality, ventricular arrhythmias & symptoms of angina pectoris in patients with acute myocardial infarction[5]
Dosage
Tabs: 250 & 330 mg.
Solution: 100 mg/mL
Adverse effects
- not common (1-10%)
- L-carnitine is converted by gut bacteria to trimethylamine-N-oxide
- plasma levels of trimethylamine-N-oxide correlate with risk of cardiovascular disease[3]
Laboratory
More general terms
More specific terms
Additional terms
Component of
- alpha tocopherol/carnitine/palmitoylascorbate/ubiquinone
- alpha tocopherol/carnitine/coenzyme/ubiquinone
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ 3.0 3.1 Koeth RA et al Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine. April 7, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23563705 <Internet> http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3145.html
Backhed F. Meat-metabolizing bacteria in atherosclerosis. Nat Med 2013 May; 19:533 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23652100 - ↑ Wikipedia: Carnitine http://en.wikipedia.org/wiki/Carnitine
- ↑ 5.0 5.1 DiNicolantonio JJ et al L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis. Mayo Clin Proc 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23597877 <Internet> http://www.mayoclinicproceedings.org/webfiles/images/journals/jmcp/jmcp_ft88_4_2.pdf