pimecrolimus (Elidel)
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Introduction
Tradename: Elidel.
Indications
- topical agent for treatment of mild to moderate eczema
- severe cases of lichen planus
Dosage
apply BID
Elidel: 1% pimecrolimus
Adverse effects
- may cause feeling of skin warmth or burning, esp in 1st few days
- photosensitivity (use sunscreen)
- increased risk of skin cancer[4][6]
Mechanism of action
- non-steroid topical immunosuppressive agent
- suppresses release of cytokines from T-cells & mast cells
- IL-2 inhibitor ?
- inhibits calcineurin (calcineurin inhibitor)
Notes
Manufacturer: Novaritis
More general terms
Additional terms
References
- ↑ Prescriber's Letter 9(2):S1 2002
- ↑ Prescriber's Letter 9(3):13 2002
- ↑ 3.0 3.1 Journal Watch 22(16):128, 2002 Wahn U et al Pediatrics 110:e2, 2002
- ↑ 4.0 4.1 Prescriber's Letter 12(4): 2005 FDA Public Health Advisory Elidel (pimecrolimus) Cream and Protopic (tacrolimus) Ointment Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210407&pb=PRL (subscription needed) http://www.prescribersletter.com http://www.fda.gov/bbs/topics/ANSWERS/2005/ANS01343/htm
- ↑ 5.0 5.1 Journal Watch 25(9):75, 2005 Ashcroft DM, Dimmock P, Garside R, Stein K, Williams HC. Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials. BMJ. 2005 Mar 5;330(7490):516. Epub 2005 Feb 24. Review. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15731121 <Internet> http://bmj.bmjjournals.com/cgi/content/full/330/7490/503
- ↑ 6.0 6.1 FDA Medwatch http://www.fda.gov/medwatch/safety/2006/safety06.htm#Elidel
- ↑ WebMD Topical Calcineurin Inhibitors for Atopic Dermatitis. http://www.webmd.com/skin-problems-and-treatments/eczema/topical-calcineurin-inhibitors-for-atopic-dermatitis
Database
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6509979
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6447131
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=17753757
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=16051947
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=24847863
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3055172
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=53486290
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=53394893
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=71751667