drug adverse effects of calcineurin inhibitors
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Adverse effects
- hypertension (treated with thiazide diuretics)
- oral calcineurin inhibitors cyclosporine & tacrolimus are associated with excess risk for non-melamoma skin cancers & lymphomas
- topical calcineurin inhibitors tacrolimus & pimecrolimus are not[3]
- topical calcineurin inhibitors are associated with increased risk of lymphomas (RR=1.9)[4]
More general terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 18 American College of Physicians, Philadelphia 2018
- ↑ Moes AD, Hesselink DA, Zietse R et al Calcineurin inhibitors and hypertension: a role for pharmacogenetics? Pharmacogenomics. 2014 Jun;15(9):1243-51. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25141899
- ↑ 3.0 3.1 Asgari MM et al. Association between topical calcineurin inhibitor use and keratinocyte carcinoma risk among adults with atopic dermatitis. JAMA Dermatol 2020 Aug 12; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/32785626 https://jamanetwork.com/journals/jamadermatology/fullarticle/2768937
- ↑ 4.0 4.1 Lam M, Zhu JW, Tadrous M et al Association Between Topical Calcineurin Inhibitor Use and Risk of Cancer, Including Lymphoma, Keratinocyte Carcinoma, and Melanoma. A Systematic Review and Meta-analysis. JAMA Dermatol. Published online March 31, 2021 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33787818 https://jamanetwork.com/journals/jamadermatology/fullarticle/2778024