chronic kidney disease epidemiology (CKD-EPI) collaboration equation
Jump to navigation
Jump to search
Indications
- the CKD-EPI equation is widely recommended for estimating GFR in adults, including the elderly, due to its practicality & reasonable accuracy[4]
- estimates of GFR using cystatin C outperform estimates based on creatinine alone, especially in older patients & patients of color
- CKD-EPI formula is recommended by the National Kidney Foundation & the American Society of Nephrology (GRS12)[6]
Principle
- complicated, ambiguous description[1]
- uses minimum & maximum serum creatinine raised to [exp 1.209]
- version that uses both minimum & maximum serum creatinine & minimum & maximum serum cystatin-C all raised to a different power
- uses age
- uses fudge factors for gender (female) & race (black)
Notes
* Modification of Diet in Renal Disease
Components
References
- ↑ 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 17, 18. American College of Physicians, Philadelphia 2015, 2018
- ↑ Inker LA, Eckfeldt J, Levey AS et al Expressing the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) cystatin C equations for estimating GFR with standardized serum cystatin C values. Am J Kidney Dis. 2011 Oct;58(4):682-4. PMID: https://pubmed.ncbi.nlm.nih.gov/21855190 Free PMC Article
- ↑ Levey AS, Fan L, Eckfeldt JH, Inker LA. Cystatin C for glomerular filtration rate estimation: coming of age. Clin Chem. 2014 Jul;60(7):916-9. PMID: https://pubmed.ncbi.nlm.nih.gov/24871681 Free Article
- ↑ 4.0 4.1 Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease Kidney Int. 2024. PMID: https://pubmed.ncbi.nlm.nih.gov/38490803 https://www.kidney-international.org/article/S0085-2538(23)00766-4/fulltext
- ↑ Spencer S, Desborough R, Bhandari S. Should Cystatin C eGFR Become Routine Clinical Practice? Biomolecules. 2023 Jul 5;13(7):1075. PMID: https://pubmed.ncbi.nlm.nih.gov/37509111 PMCID: PMC10377068 Free PMC article. Review. https://pmc.ncbi.nlm.nih.gov/articles/PMC10377068/
- ↑ 6.0 6.1 Geriatric Review Syllabus, 12th edition (GRS12) Colburn JL, Wescott AM, Potter JF (eds) American Geriatrics Society, 2025