protein synthesis initiation

Introduction

see figure

Biochemistry

• protein synthesis 1
  • enzyme: GDP-GTP dissociation stimulator
  • substrate: eukaryotic initiation factor 2 - subunits: EIF2-alpha (Ser-P, GDP) + EIF2-beta + GTP
  • product: eukaryotic initiation factor 2 - subunits: EIF2-alpha (Ser-P, GTP) + EIF2-beta + GDP
• protein synthesis 2
  • substrate: eukaryotic initiation factor 2 - subunits: EIF2-alpha (Ser-P, GTP) + EIF2-beta + transfer-RNA :amino-acyl met
  • product: macromolecular complex - components: EIF2-alpha (Ser-P, GTP) + EIF2-beta + transfer-RNA :amino-acyl met
• protein synthesis 3
  • substrate: eukaryotic initiation factor 3 + 40S-ribosomal subunit
  • product: macromolecular complex - components: 40S-ribosomal subunit + eukaryotic initiation factor 3
• protein synthesis 4
  • substrate: macromolecular complex - components: 40S-ribosomal subunit + eukaryotic initiation factor 3 + macromolecular complex - components: EIF2-alpha (Ser-P, GTP) + EIF2-beta + transfer-RNA :amino-acyl met + eukaryotic initiation factor 4C
  • product: entry complex)
• protein synthesis 5
  • enzyme: eukaryotic initiation factor 4
  • substrate: entry complex + CAP binding protein + messenger RNA + ATP
  • product: 40S-preinitiation complex + ADP
• protein synthesis 6
  • enzyme: eukaryotic initiation factor 5
  • substrate: 40S-preinitiation complex + 60S-ribosomal subunit
  • product: 80S-initiation complex + eukaryotic initiation factor 2 - subunits: EIF2-alpha (Ser-P, GDP) + EIF2-beta + eukaryotic initiation factor 3 + H2PO4-

More general terms

• protein synthesis