Figure: protein synthesis initiation
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Biochemistry
- protein synthesis 1
- enzyme: GDP-GTP dissociation stimulator
- substrate: eukaryotic initiation factor 2 - subunits: EIF2-alpha (Ser-P, GDP) + EIF2-beta + GTP
- product: eukaryotic initiation factor 2 - subunits: EIF2-alpha (Ser-P, GTP) + EIF2-beta + GDP
- protein synthesis 2
- substrate: eukaryotic initiation factor 2 - subunits: EIF2-alpha (Ser-P, GTP) + EIF2-beta + transfer-RNA :amino-acyl met
- product: macromolecular complex - components: EIF2-alpha (Ser-P, GTP) + EIF2-beta + transfer-RNA :amino-acyl met
- protein synthesis 3
- protein synthesis 4
- substrate: macromolecular complex - components: 40S-ribosomal subunit + eukaryotic initiation factor 3 + macromolecular complex - components: EIF2-alpha (Ser-P, GTP) + EIF2-beta + transfer-RNA :amino-acyl met + eukaryotic initiation factor 4C
- product: entry complex)
- protein synthesis 5
- enzyme: eukaryotic initiation factor 4
- substrate: entry complex + CAP binding protein + messenger RNA + ATP
- product: 40S-preinitiation complex + ADP
- protein synthesis 6
- enzyme: eukaryotic initiation factor 5
- substrate: 40S-preinitiation complex + 60S-ribosomal subunit
- product: 80S-initiation complex + eukaryotic initiation factor 2 - subunits: EIF2-alpha (Ser-P, GDP) + EIF2-beta + eukaryotic initiation factor 3 + H2PO4-