translation initiation factor IF-2, mitochondrial; IF-2Mt; IF2(mt); IF-2(Mt) (MTIF2)

Function

• one of the essential components for the initiation of mitochondrial protein synthesis
• protects formylmethionyl-tRNA from spontaneous hydrolysis & promotes its binding to the 30S ribosomal subunits
• also involved in the hydrolysis of GTP during the formation of the mitochondrial 70S ribosomal complex
• monomer

Structure

belongs to the IF-2 family

Compartment

mitochondria

Expression

• expressed in all tissues examined
• highest level in skeletal muscle

More general terms

• initiation factor
• mitochondrial protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P46199.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4528
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4528
• OMIM: https://mirror.omim.org/entry/603766