Hodgkin's disease, lymphocyte depleted type

Epidemiology

• least common variant of Hodgkin's disease.
• more common in older people and HIV+ individuals.

Pathology

• diffuse infiltrate, often hypocellular
• large numbers of Reed-Sternberg cells & bizarre variants

Immunophenotype

tumor cells

• CD15 +/-
• CD30 +
• CD45 -
• B-cell & T-cell antigens - (required for diagnosis)
• EMA -

Genetics

• Ig & TCR genes germline

Clinical manifestations

• frequently abdominal lymphadenopathy, spleen, liver & bone marrow involvement without peripheral adenopathy
• usually advanced stage at diagnosis
• response to treatment similar to other subtypes

More general terms

• Hodgkin's disease (Hodgkin's lymphoma)