ELAV-like protein 4; paraneoplastic encephalomyelitis antigen HuD; Hu-antigen D (ELAVL4, HUD, PNEM)

Function

• may play a role in neuron-specific RNA processing
• protects CDKN1A mRNA from decay by binding to its 3'-UTR
• binds to AU-rich sequences (AREs) of target mRNAs, including VEGF & FOS mRNA
• methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA & down-regulates CDKN1A protein expression, thus maintaining cells in a proliferative state
• methylation is inhibited by NGF, which facilitates neurite outgrowth (putative)
• component of a TAU mRNP complex

Structure

• belongs to the RRM elav family
• contains 3 RRM domain (RNA recognition motif)s

Alternative splicing

named isoforms=4

Expression

brain

Pathology

• autoantigen in paraneoplastic encephalomyelitis

Laboratory

• HuD Ab in serum/plasma

More general terms

• RNA-binding protein
• antigen

Database

• UniProt: http://www.uniprot.org/uniprot/P26378.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1996
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1996
• OMIM: https://mirror.omim.org/entry/168360