NACHT, LRR & PYD-containing protein 1; death effector filament-forming ced-4-like apoptosis protein; nucleotide-binding domain & caspase recruitment domain; caspase recruitment domain protein 7 (DEFCAP, KIAA0926, NALP1, NLRP1, CARD7, DEFCAP-L)

Function

• forms cytoplasmic structures termed death effector filaments
• enhances APAF1 & cytochrome C-dependent activation of pro-caspase-9 & consecutive apoptosis
• binds ATP
• interacts with caspase-2, weakly with caspase-9 & with APAF1, leads to formation of apoptosome (ATP-dependent)

Structure

• contains 1 CARD domain contains 1 DAPIN domain contains 7 LRR repeats (leucine-rich repeats) contains 1 NACHT domain

Compartment

cytoplasm

Alternative splicing

named isoforms=4

Expression

• widely expressed
• isoforms 1 & 2 are expressed in peripheral blood leukocytes > thymus, spleen, heart
• detected in lung, placenta, small intestine, colon, kidney, liver, muscle

Pathology

• expressed in chronic myelogenous leukemia cell line K-562

More general terms

• pro apoptotic protein
• NACHT, LRR & PYD-containing protein (NALP)

Additional terms

• apoptosis

Database

• OMIM: https://mirror.omim.org/entry/606636
• UniProt: http://www.uniprot.org/uniprot/Q9C000.html