GDNF family receptor alpha-1; GFR-alpha-1; glial derived neurotrophic factor [GDNF] receptor alpha-1; TGF-beta-related neurotrophic factor receptor 1; RET ligand 1 (GFRA1, GDNFRA, RETL1, TRNR1)

Function

• receptor for GDNF
• mediates the GDNF-induced autophosphorylation & activation of the RET receptor
• 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer & with 2 molecules of RET

Structure

• belongs to the GDNFR family
• glycosylphosphatidylinositol-linked cell surface receptor

Compartment

cell membrane; lipid-anchor, GPI-anchor

Alternative splicing

named isoforms=2

Notes

may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• glial derived neurotrophic factor [GDNF] receptor alpha

Additional terms

• glial-derived neurotrophic factor; hGDNF; astrocyte-derived trophic factor; ATF (GDNF)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2674
• OMIM: https://mirror.omim.org/entry/601496
• UniProt: http://www.uniprot.org/uniprot/P56159.html