BNP receptor; basic (brain) natriuretic peptide [BNP] receptor; atrial natriuretic peptide receptor B; ANP-B; ANPRB; GC-B; guanylate cyclase B; NPR-B; atrial natriuretic peptide B-type receptor (NPR2, ANPRB)

Function

• receptor for
  • atrial natriuretic peptide (ANP)
  • brain natriuretic peptide (BNP)
  • C-type natriuretic peptide (CNP)
• has guanylate cyclase activity on binding of ligand
• activation order seems to be CNP > BNP > ANP
• phosphorylation of the protein kinase-like domain is required for full activation by CNP (putative)

Structure

• belongs to the adenylyl cyclase class-4/ guanylyl cyclase family
• contains 1 guanylate cyclase domain
• contains 1 protein kinase domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Pathology

• defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type

More general terms

• natriuretic peptide receptor
• guanyl cyclase or guanylate cyclase
• phosphoprotein
• glycoprotein

Additional terms

• basic (brain) natriuretic peptide (BNP, B-type)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4882
• OMIM: https://mirror.omim.org/entry/108961
• OMIM: https://mirror.omim.org/entry/602875
• UniProt: http://www.uniprot.org/uniprot/P20594.html