mast cell immunoreceptor signal transducer (cytokine-dependent hematopoietic cell linker, MIST, CLNK)

Function

• plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling & FC-epsilon R1-mediated mast cell degranulation
• involved in phosphorylation of LAT (putative)
• when phosphorylated, interacts with PLCG1, PLCG2, GRB2, VAV & LAT (putative)
• Tyr-phosphorylated upon BCR cross-linking
• Tyr phosphorylation at both Tyr-69 & Tyr-96 are required for BCR-induced Ca+2 response & are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40 cells, but this phosphorylation is dispensable in cells expressing LAT
• interacts with the SH2 domain of PLCG1 via phosphorylated Tyr-96

Structure

• N-terminal proline-rich region interacts with the SH3 domain of PLCG1 (putative)
• SH2 domain is important for restoration of BCR-induced Ca+2 response & JNK2 activation in BLNK-deficient DT40 cells expressing LAT (putative)
• contains 1 SH2 domain

Alternative splicing

named isoforms=3

More general terms

• receptor
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1164
• UniProt: http://www.uniprot.org/uniprot/Q7Z7G1.html