Helicase ARIP4 (androgen receptor-interacting protein 4, RAD54-like protein 2, RAD54L2, ARIP4, KIAA0809)

Function

• DNA helicase
• modulates androgen receptor (AR)-dependent transactivation (promoter-dependent)
• not able to remodel mononucleosomes in vitro (putative)
• interacts with AR via its N-terminus
• interacts with DYRK1A
• binds DNA & mononucleosomes, but does not seem to form large multiprotein complexes (putative)
• enzyme activity is enhanced by dsDNA (double-stranded DNA) & ssDNA (single-stranded DNA) (putative)
• sumoylated (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors
• belongs to the SNF2/RAD54 helicase family
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

• nucleus (putative)
• localizes in speckle-like nuclear compartments (putative)

More general terms

• receptor
• helicase (DNA unwinding protein, DNA untwisting protein)
• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y4B4.html