CD201; endothelial protein C receptor; activated protein C receptor; APC receptor (PROCR)

Function

• binds activated protein C
• role in protein C pathway control of blood coagulation
• enhances protein C activation by thrombin-thrombomodulin complex
• binds protein C (Ca+2 dependent)

Structure

• N-glycosylated

Compartment

• soluble & membrane forms
• soluble form probably released by a metalloprotease
• seems to have the same activity as the membrane-bound form

Expression

• expressed in endothelial cells
  • arteries & veins in heart & lung (strong expression)
  • capillaries in the lung & skin (less strong)
• not expressed in small vessels of liver & kidney

Pathology

• mutations associated with
  • venous thromboembolism
  • myocardial infarction
  • late fetal loss during pregnancy

More general terms

• CD antigen
• receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1054
• OMIM: https://mirror.omim.org/entry/600646
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10544
• UniProt: http://www.uniprot.org/uniprot/Q9UNN8.html