protein kinase G type-1; cGMP-dependent protein kinase type-1; cGMP-dependent protein kinase alpha (PRKG1, PRKGR1A, PRKG1B, PRKGR1B)
Jump to navigation
Jump to search
Function
- serine/threonine protein kinase
- binding of cGMP results in enzyme activation
- substrate specificity similar but not identical to CAK
- part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 & ITPR1 (putative)
- interacts with MRVI1
Structure
- antiparallel homodimer
- belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, cGMP subfamily
- contains 1 AGC-kinase C-terminal domain
- contains 2 cyclic nucleotide-binding domains
- contains 1 protein kinase domain
Alternative splicing
named isoforms=2
Genetics
- cGMP protein kinase-1 alpha & beta subunits produced from same transcript by alternative splicing.
More general terms
References
- ↑ Armstrong DL Calcium channel regulation by calcineurin, a Ca+2-activated phosphatase in mammalian brain TINS 12(3):117 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2469218
- ↑ Nestler & Greengard Basic Neurochemistry ch 19 1989
- ↑ Lincoln TM, Cornwell TL. Intracellular cyclic GMP receptor proteins. FASEB J. 1993 Feb 1;7(2):328-38. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7680013