calponin-1; calponin H1, smooth muscle; basic calponin (CNN1)

Function

• thin filament-associated protein that is implicated in regulation & modulation of smooth muscle contraction
• capable of binding to actin, calmodulin, troponin C & tropomyosin
• interaction of calponin with actin inhibits actomyosin Mg-ATPase activity (putative)
• part of cGMP kinase signaling complex

Structure

• belongs to the calponin family
• contains 3 calponin-like repeats
• contains 1 CH (calponin-homology) domain

Expression

• smooth muscle, & tissues containing significant amounts of smooth muscle

More general terms

• calponin

Component of

• cGMP kinase signaling complex

Database

• UniProt: http://www.uniprot.org/uniprot/P51911.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1264
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1264
• OMIM: https://mirror.omim.org/entry/600806