actin, aortic smooth muscle; alpha-actin-2; cell growth-inhibiting gene 46 protein (ACTA2, ACTSA, ACTVS, GIG46)

Function

• alpha-actins are a major constituent of the contractile apparatus
• polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix
• each actin can bind to 4 others

Structure

belongs to the actin family

Compartment

cytoplasm, cytoskeleton

Expression

• alpha-actins are found in muscle tissues

Pathology

• defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6

More general terms

• alpha actin

Database

• UniProt: http://www.uniprot.org/uniprot/P62736.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=59
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:59
• OMIM: https://mirror.omim.org/entry/102620
• OMIM: https://mirror.omim.org/entry/611788